This study presents a novel bio-inspired method, based on gain scheduling, for the calculation of Proportional-Integral-Derivative (PID) controller parameters that will prevent system instability. The aim is to prevent a transition to control system instability due to undesirable controller parameters that may be introduced manually by an operator. Each significant operation point in the system is firstly identified. Then, a solid stability structure is calculated, using transfer functions, in order to program a bio-inspired model by using an artificial neural network. The novel method is empirically verified under working conditions in a liquid-level laboratory plant.