Neuro-symbolic hybrid systems (NSHS) have been used in several research areas to obtain powerful intelligent systems. A systematic mapping study was conducted, searching studies published from January 2011 to May 2018 in three author databases defining four research questions and three search strings. With the results a literature review was made to generate a map with main trends and contributions about the use of NSHS in Industry 4.0. An evaluation rubric based on the work of Petersen et al. (2015) was applied too. In a first exploratory search 544 papers was found, but only 330 had relation with research theme. After this first classification a second filter was applied to identify repeated articles or which had not relevance for solve the research questions, obtaining 118. Finally, 50 primary studies was selected. This paper is a guide aimed at researching and obtaining evidence on the shortage of publications and contributions about the use of neuro symbolic hybrid systems applied in Industry 4.0 environment.